1. 个人简介

王心梅，工学博士，副教授，硕士生导师，从事心脏瓣膜相关研究，主要包括环境因子和其他疾病诱导的心脏瓣膜退变机理、利用微流体板构建器官模型、利用新型生物材料合成人工组织、利用新型生物材料和3D打印技术探究健康课题等。近年来在Annals of Biomedical Engineering等国外重要专业学术期刊上发表SCI收录论文十余篇。

职称职务：副教授

主讲课程： 普通生物学，生物工程工厂设计

研究方向：生物医学工程，组织工程

办公电话：

电子邮箱： xinmwang@syu.edu.cn

2. 教育经历

2008.08 - 2012.06，大连理工大学，精细化工专业，本科

2012.08 - 2017.08,Texas Tech University,Department of Chemical Engineering, Ph.D.

3. 工作经历

2018.05 -2019.07, Texas Tech University,Department of Chemical Engineering, PostDoc researcher

2019. 10 - 2020.10，沈阳大学，科技创新研究院，副教授

2020.10 -今，沈阳大学，生命科学与工程学院，副教授

4. 科研项目

[1]

5. 论文、教材、著作、专利

[1]X. Wang, P. Lapuerta and C.M.R. Lacerda. Telotristat ethylreverses myxomatous changes in mice mitral valves. Front. Cardiovas. Med. 2022; https://doi.org/10.3389/fcvm.2022.945672

[2]X. Wang, N. Deb, and C.M.R. Lacerda. Comparison of serotonin-regulated calcific processes in aortic and mitral valvular interstitial cells. ACS Omega. 2021; 6(30):19494-19505

[3]X. Wang, M.S. Ali, and C.M.R. Lacerda. Osteogenesis inducers promote distinct biological responses in aortic and mitral valve interstitial cells. J Cell Biochem. 2019; 120(7):11158-11171.

[4] M.S. Ali,X. Wang, and C.M.R. Lacerda. The effect of physiological stretch and the valvular endothelium on mitral valve proteomes.Exp Biol Med. 2019; 244(3):241-251.

[5] X. Wang, M.S. Ali, and C.M.R. Lacerda. A Three-Dimensional Collagen-Elastin Scaffold for Heart Valve Tissue Engineering.Bioengineering. 2018; 5(3):69.

[6] J. Lee, Z. Estlack, H. Somaweera,X. Wang, C.M.R. Lacerda and J.J. Kim. A microfluidic cardiac flow profile generator for studying the effect of shear stress on the valvular endothelial cell.Lab Chip. 2018; 18(19):2946-2954.

[7] M.S. Ali, N. Deb,X. Wang, M. Rahaman, G.F. Christopher and C.M.R. Lacerda. Correlation between valvular interstitial cell morphology and phenotypes: A novel way to detect activation.Tissue Cell. 2018; 54:38-46

[8] M.S. Ali,X. Wang, and C.M.R. Lacerda. Progenitor Subpopulations of Valvular Cells Resembling Hematopoietic and Mesenchymal Stem Cells and their Role in Myofibroblastic Activation.J Regen Med. 2018; 7:1. doi: 10.4172/2325-9620.1000141

[9] X. Wang, J. Lee, M.S. Ali, J. Kim, and C.M.R. Lacerda. Phenotypetransformation ofaorticvalveinterstitialcellsdue toappliedshearstresseswithin amicrofluidicchip.Ann Biomedi Eng. 2017; 45(10):2269-2280.

[10] M.S. Ali,X. Wang, and C.M.R. Lacerda. A survey of membrane receptor regulation in valvular interstitial cells cultured under mechanical stresses.Exp Cell Res. 2017; 351(2):150-156.

[11] M.S. Ali,X. Wang, M. Dinh, A. Curtis, M. Kim, E. Hui, and C.M.R. Lacerda. Effect of Cell Migration and Endothelial Cell Contact Upon Phenotype Activation of Valvular Interstitial Cells.Cardiology. 2016; 134(2):217-217.

[12] J. Lee, M.E. Razu,Wang X., Lacerda C.M.R and J.J. Kim. Biomimetic cardiac microsystems for pathophysiological studies and drug screens.J Lab Autom. 2015; 20(2):96-106.

5.荣誉获奖、人才称号、学术任职

[1] 沈阳市支持留学归国博士来沈创新创业奖励

[2] 沈阳市拔尖人才